Abstract. This single-group clinical trial evaluated the effects of Despi® Legion pressure-point insoles on men's vitality and wellness over 12 weeks. Thirty-five male participants aged 45–70 wore the test insoles in their everyday footwear each day, from morning to evening, and changed nothing else — no new diet, no new training plan, no supplements. Participants completed questionnaires at Baseline, Week 4, Week 8, and Week 12. By Week 12, all 10 evaluated vitality, overall wellness, and brain fog parameters showed significant improvement. Participant perception data revealed strong satisfaction, with 8 of 13 product-related statements receiving ≥50% agreement by Week 12, including improvements in energy levels, sex drive, sleep, and brain fog. These results suggest that Despi® Legion pressure-point insoles effectively enhance multiple aspects of men's overall wellness and vitality, including energy levels, sex drive, motivation, brain fog, stress management, and sleep. Further large-scale, controlled studies are recommended to validate and expand on these outcomes.
Men's vitality and overall wellness often diminish with age, primarily due to declining testosterone levels, a condition known as late-onset hypogonadism or "low T". Testosterone is a key hormone that regulates sexual function, muscle mass, energy levels, mood, cognitive performance, and bone density. Symptoms of low testosterone can include reduced libido, fatigue, decreased muscle mass, increased body fat, and mood disturbances.
As men age, testosterone levels naturally decrease, but for some, the drop is more pronounced, leading to significant impacts on quality of life and long-term health. Addressing this decline is important for maintaining men's vitality, sexual health, and metabolic well-being.
The soles of the feet are among the most densely innervated regions of the human body. For most of human history, men stood, walked, and fought on surfaces that pressed into this network of plantar nerve endings all day long. Modern cushioned footwear flattens and mutes that input, leaving the body's base signal largely dormant during the hours a man spends on his feet.
Despi® Legion insoles were engineered to restore that input: a pressure-point base of rounded raised nodes and a supportive foot hold that press into the plantar surface with every step and every hour of standing. This study aimed to evaluate the effects of Despi® Legion pressure-point insoles on men's vitality and wellness over 12 weeks.
A total of 35 male participants aged 45–70 were recruited for this study. All participants reported concerns with brain fog, low energy, poor sleep, low libido, low confidence, and feeling stressed, and satisfied the inclusion and exclusion criteria outlined in the study protocol.
This was a virtual single-group clinical trial that lasted for 12 weeks. Consent forms describing the study process, instructions, evaluation methods, and bill of rights were provided to participants before study onboarding. Following the consent process, participants completed the Baseline questionnaire. Participants were asked to place the test insoles in the pair of shoes they wore most, and to wear them through their normal day — work days, workouts, and everything in between — every day of the trial. No changes to diet, training, or supplementation were requested. Further questionnaires were completed at the end of Week 4, Week 8, and Week 12.
Data from the questionnaires were collected using a textual 5-point Likert scale for each question. The textual Likert data were transformed into numerical values of 1–5. For nine questions, 1 represented the worst outcome, and 5 represented the best outcome. For one question, 1 represented the best outcome, and 5 represented the worst outcome. Data were checked for normality and analyzed using a two-way ANOVA test with Dunnett's multiple comparisons test. The significance level was set at 0.05. For product-specific questions not evaluated at Baseline, results were presented as the percentage of subjects reporting each answer.
Included in the questionnaires was a quality check question to assess participant engagement. Participants who did not answer "Agree" or "Strongly Agree" to the question were excluded from all questionnaire analyses at that time point. One participant was excluded from each of the Week 4, Week 8, and Week 12 questionnaire analyses.
The effect of Despi® Legion pressure-point insoles on 10 vitality, overall wellness, and brain fog parameters was evaluated at Baseline, Week 4, Week 8, and Week 12.
By Week 4, all 10 parameters were significantly improved from the Baseline, including increased energy levels, drive/motivation, sex drive, sleep pattern regularity, ability to gain muscle through exercise, posture and stability, overall confidence, ability to stay calm in high-pressure situations, and stress management, and a decrease in the frequency of brain fog/difficulty concentrating (Table 1, Table 2, Figure 1). The most notable improvement was a 45.41% increase in the sex drive score (Table 1, Figure 1).
By Week 8, all 10 parameters continued to improve significantly from Baseline (Table 1, Table 2, Figure 1). The most notable improvements included a 56.33% increase in the sex drive score, a 50.43% increase in the drive/motivation score, and a 48.64% increase in the stress management skills score (Table 1, Figure 1).
By Week 12, all 10 parameters improved significantly from Baseline (Table 1, Table 2, Figure 1). Notable improvements included a 55.02% increase in the sex drive score, a 52.68% increase in the sleep pattern regularity score, a 52.14% increase in the overall confidence score, and a 36.76% decrease in the brain fog/difficulty concentrating score (Table 1, Table 2, Figure 1).
Participants were asked to respond to questions at the end of Week 4, Week 8, and Week 12, which provided insight into their perceptions of the test product. They responded to product evaluation questions with a "strongly agree" to "strongly disagree" scale. The "strongly agree" and "agree" responses were combined into a single "combined agree" result to evaluate the overall participant perception.
In Week 4, 3 of the 11 parameters showed ≥50% participant agreement (Table 3). These included 'since I started wearing this product, my energy levels have increased' (54.55%), 'since I started wearing this product, my ability to stay calm in high-pressure situations has improved' (57.58%), and 'since I started wearing this product, my ability to handle stress has improved' (51.52%) (Table 3).
In Week 8, 7 of the 11 parameters showed ≥50% participant agreement, including 'since I started wearing this product, my drive (motivation) has increased' (57.58%), 'since I started wearing this product, my brain fog has lifted' (54.55%), 'since I started wearing this product, my sex drive has improved' (60.61%), and 'since I started wearing this product, my posture and stability have improved' (54.55%) (Table 3). All other parameters from Week 4 were maintained.
In Week 12, 8 of the 13 parameters showed ≥50% participant agreement (Table 3). These included 'since I started wearing this product, my energy levels have increased' (63.64%), 'since I started wearing this product, my drive (motivation) has increased' (54.55%), 'since I started wearing this product, my brain fog has lifted' (54.55%), 'since I started wearing this product, my sex drive has improved' (60.61%), 'since I started wearing this product, my sleep has improved' (57.58%), 'since I started wearing this product, my ability to stay calm in high-pressure situations has improved' (57.58%), 'I would like to continue using this product' (81.82%), and 'I would recommend this product to my family and friends' (75.76%) (Table 3).
No adverse events attributable to the test product were reported during the trial. Two participants reported unrelated minor events; both indicated these were attributable to factors other than the test product.
| Question | Baseline (N=35) | Week 4 (N=33) | Week 8 (N=33) | Week 12 (N=33) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | STD | Mean | STD | P-Value | % Change | Mean | STD | P-Value | % Change | Mean | STD | P-Value | % Change | |
| Over the past four weeks, how would you rate your energy levels? | 2.40 | 0.74 | 3.33 | 0.74 | <0.0001 | 38.75 | 3.42 | 0.75 | <0.0001 | 42.50 | 3.52 | 0.87 | <0.0001 | 46.67 |
| Over the past four weeks, how would you rate your drive (motivation)? | 2.34 | 0.64 | 3.24 | 0.75 | <0.0001 | 38.46 | 3.52 | 0.67 | <0.0001 | 50.43 | 3.48 | 0.87 | <0.0001 | 48.72 |
| Over the past four weeks, how would you describe your sex drive? | 2.29 | 0.79 | 3.33 | 1.05 | <0.0001 | 45.41 | 3.58 | 0.94 | <0.0001 | 56.33 | 3.55 | 1.00 | <0.0001 | 55.02 |
| Over the past four weeks, how regular has your sleep pattern been? | 2.31 | 0.93 | 3.27 | 0.91 | <0.0001 | 41.56 | 3.33 | 1.05 | <0.0001 | 44.16 | 3.52 | 1.00 | <0.0001 | 52.68 |
| Over the past four weeks, how would you rate your ability to gain muscle through exercise? | 2.20 | 0.72 | 3.06 | 0.70 | <0.0001 | 39.09 | 3.18 | 0.81 | <0.0001 | 44.55 | 3.15 | 0.91 | <0.0001 | 43.18 |
| Over the past four weeks, how would you rate your posture and stability? | 2.91 | 0.82 | 3.64 | 0.78 | 0.001 | 25.09 | 3.76 | 0.61 | <0.0001 | 29.21 | 3.67 | 0.89 | 0.0006 | 26.12 |
| Over the past four weeks, how would you rate your overall confidence? | 2.57 | 0.88 | 3.73 | 0.76 | <0.0001 | 45.14 | 3.76 | 0.71 | <0.0001 | 46.30 | 3.91 | 0.88 | <0.0001 | 52.14 |
| Over the past four weeks, how would you rate your ability to stay calm in high-pressure situations? | 2.80 | 0.96 | 3.91 | 0.77 | <0.0001 | 39.64 | 3.91 | 0.68 | <0.0001 | 39.64 | 4.00 | 0.87 | <0.0001 | 42.86 |
| Over the past four weeks, how would you rate your stress management skills? | 2.57 | 0.92 | 3.64 | 0.82 | <0.0001 | 41.63 | 3.82 | 0.77 | <0.0001 | 48.64 | 3.79 | 0.82 | <0.0001 | 47.47 |
% Change indicates a change in mean values from the Baseline. An increase in score indicates an improvement in the vitality and overall wellness parameter. This table provides the numerical data presented in Figure 1. Green cells highlight statistically significant outcomes (P<0.05).
| Question | Baseline (N=35) | Week 4 (N=33) | Week 8 (N=33) | Week 12 (N=33) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean | STD | Mean | STD | P-Value | % Change | Mean | STD | P-Value | % Change | Mean | STD | P-Value | % Change | |
| Over the past four weeks, how often have you experienced brain fog or difficulty concentrating? | 3.40 | 0.77 | 2.48 | 0.80 | <0.0001 | -27.06 | 2.36 | 0.86 | <0.0001 | -30.59 | 2.15 | 0.76 | <0.0001 | -36.76 |
% Change indicates a change in mean values from the Baseline. A decrease in score indicates an improvement in the brain fog parameter. Green cells highlight statistically significant outcomes (P<0.05).
| How much do you agree or disagree with the following: | Week 4 (n=33) | Week 8 (n=33) | Week 12 (n=33) |
|---|---|---|---|
| Since I started wearing this product, my energy levels have increased. | 54.55% | 66.67% | 63.64% |
| Since I started wearing this product, my drive (motivation) has increased. | 45.45% | 57.58% | 54.55% |
| Since I started wearing this product, my brain fog has lifted. | 36.36% | 54.55% | 54.55% |
| Since I started wearing this product, my sex drive has improved. | 42.42% | 60.61% | 60.61% |
| Since I started wearing this product, my sleep has improved. | 48.48% | 45.45% | 57.58% |
| Since I started wearing this product, my muscle gain has improved. | 30.30% | 42.42% | 39.39% |
| Since I started wearing this product, I look and feel leaner. | 27.27% | 42.42% | 33.33% |
| Since I started wearing this product, my posture and stability have improved. | 39.39% | 54.55% | 45.45% |
| Since I started wearing this product, I have gained a newfound confidence. | 42.42% | 42.42% | 48.48% |
| Since I started wearing this product, my ability to stay calm in high-pressure situations has improved. | 57.58% | 60.61% | 57.58% |
| Since I started wearing this product, my ability to handle stress has improved. | 51.52% | 57.58% | 42.42% |
| I would like to continue using this product. | - | - | 81.82% |
| I would recommend this product to my family and friends. | - | - | 75.76% |
Blue cells highlight a combined positive response of ≥50%.
Data is graphed as group means (scale 1–5). An increase in score indicates an improvement. Grey bar = Baseline; blue bars = Week 4, 8 and 12. All shown changes are statistically significant (P<0.05).
This study evaluated the efficacy of Despi® Legion pressure-point insoles in improving men's vitality and overall wellness over 12 weeks, using a combination of participant-reported outcomes and standardized vitality, overall wellness, and brain fog parameter assessments.
Findings from the vitality, overall wellness, and brain fog parameter evaluations demonstrated steady and significant improvements across a broad range of measures. Improvements were observed as early as Week 4, with the most notable early effect being improved sex drive. By Week 12, all 10 parameters had significantly improved, including energy levels, sex drive, sleep pattern regularity, stress management skills, drive/motivation, brain fog, and overall confidence. These outcomes suggest that the Despi® Legion pressure-point insoles offer a progressive, cumulative benefit for vitality, overall wellness, and brain fog.
Participant perception data aligned closely with these findings, with early improvements in energy levels, ability to stay calm in high-pressure situations, and ability to handle stress by Week 4. By Week 12, most participants agreed that their energy levels had increased, their brain fog had lifted, their sex drive had improved, and their sleep had improved. Additionally, 81.82% of participants agreed that they would like to continue using this product. These self-reported outcomes highlight the experiential benefits users perceived throughout the trial.
Overall, the results support the potential of the Despi® Legion pressure-point insoles as an effective solution for improving multiple aspects of men's overall wellness and vitality, including energy levels, sex drive, motivation, brain fog, stress management, and sleep. The product was well-tolerated and showed both subjective and objective benefits.
The findings of this study highlight the efficacy of Despi® Legion pressure-point insoles in improving men's vitality and wellness over 12 weeks. Significant improvements were seen in key areas such as overall confidence, stress management skills, and sleep pattern regularity, with the most notable improvement being increased sex drive. Participant feedback reflected strong satisfaction with the product, including perceived improvements in energy levels, brain fog, sex drive, and sleep. These results suggest that Despi® Legion pressure-point insoles are an effective, well-tolerated option for men seeking to improve vitality and overall wellness without pills, hormones, or injections. Further research with a larger population could help validate and expand upon these promising findings.
Results are self-reported by trial participants and individual results vary. Despi® Legion insoles are not a medical device and are not intended to diagnose, treat, cure or prevent any disease. Questions? support@trydespi.com